THRIVE stands for "The Study of Host-bacterial Relationships and Immune function in different Vaginal Environments". This study aims to understand how the vaginal environment is working differently for different women, how bacterial vaginosis contributes to this environment, and what components of the environment associates with successful treatment of bacterial vaginosis.
Approximately 30% of women experience bacterial vaginosis (BV), but what is BV? Bacterial vaginosis is a clinical diagnosis of a vaginal infection that causes discharge, odor and irritation, and is associated with a high bacterial diversity inside the vagina and negative reproductive health outcomes, such as pelvic inflammatory disease, infertility, pre-term birth, low birth weight, and miscarriage.
Bacterial vaginosis is normally diagnosed by a pH test, gram stain (to test for bacterial presence) and Whiff test (odor test). BV is treated by taking an oral pill twice daily for 7 days, or by applying a gel or cream daily for 5-7 days. Treatment with BV is initially successful for about 85% of people taking medication, however recurrence rates are 50% within 12 months of initial treatment. Because of this poor long term treatment success rate, a better understanding of how BV bacteria interact with the host is needed to discover better treatment options.
THRIVE is made up of a team of research scientists, clinicians and nurses all working together to study what causes bacterial vaginosis, and how to find a better, long lasting treatment.
Participants will be seen by nurses and gynaecologists from the Women’s Health
Research Program located at the Health Sciences Centre in Winnipeg, Manitoba.
Clinical and self collected samples taken for this study will be brought to the research laboratory site located at the JC Wilt Infectious Diseases Research Centre in Winnipeg, Manitoba. All samples will anonymous to research scientists, and will be used to determine how the bacterial environment, host immune system and external factors (such as diet, hygiene and sexual practices) relate to the recurrence rate of bacterial vaginosis.
For any questions or if you are interested in participating, please contact us at:
(Health Sciences Centre)
715 McDermot Avenue, Winnipeg, Manitoba R3E 3P4, Canada
Please leave a message if you receive voicemail!